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LeBron James scored 16 points and Bosh added eight the two Heat stars look ready for the regular season. Dwyane Wade also played for the first time this season.
The Heat lead the Clippers 53-35 at the half.
LeBron James led Miami with 16 points, including a few big slams, while Chris Bosh dropped eight and Ray Allen netted six for Miami. Dwyane Wade has scored two points in his return to action.
The Clippers, playing with Chris Paul, looked inefficient and sloppy in the first half while Miami's defensive rotations looked sharp.